| World Group Play Offs | 04/21 11:25 | - | Karolina Muchova v Leylah Annie Fernandez | Cancelled | |
| 2019 Fed Cup | 04/20 11:30 | - | [106] Karolina Muchova v Rebecca Marino [184] | 6-3,6-0 | |
| WTA Monterrey | 04/05 01:40 | 26 | [5] Angelique Kerber v Karolina Muchova [109] | 6-3,6-4 | |
| WTA Monterrey | 04/02 21:30 | 25 | [206] Shilin Xu v Karolina Muchova [109] | 4-6,7-5,3-6 | |
| WTA Miami | 03/22 20:10 | 24 | [113] Karolina Muchova v Angelique Kerber [4] | 6-3,3-6,3-6 | |
| WTA Miami | 03/21 20:40 | 23 | [113] Karolina Muchova v Nao Hibino [119] | 6-3,6-3 | |
| WTA Miami | 03/20 15:40 | 45 | [116] Marie Bouzkova v Karolina Muchova [113] | 4-6,3-6 | |
| WTA Miami | 03/18 20:20 | 44 | [113] Karolina Muchova v Vitalia Diatchenko [106] | 7-6,6-1 | |
| WTA Doha | 02/14 12:30 | 27 | [7] Elina Svitolina v Karolina Muchova [132] | 6-4,6-2 | |
| WTA Doha | 02/13 12:30 | 26 | [31] Su-Wei Hsieh v Karolina Muchova [132] | 2-6,4-6 | |
| WTA Doha | 02/12 14:45 | 25 | [132] Karolina Muchova v Samantha Stosur [73] | 6-4,6-2 | |
| WTA Doha | 02/12 13:30 | - | Karolina Muchova v Caroline Wozniacki | Cancelled | |
| WTA Doha | 02/11 12:30 | 54 | [167] Liudmila Samsonova v Karolina Muchova [132] | 1-6,6-3,1-6 | |
| WTA Doha | 02/10 12:30 | 46 | [133] Karolina Muchova v Kristyna Pliskova [90] | 6-3,4-6,6-4 | |
| WTA Doha | 02/09 08:00 | 45 | Mubaraka Al-Naimi v Karolina Muchova | 0-6,0-6 | |
| Australian Open Women | 01/15 00:00 | 23 | [139] Karolina Muchova v Karolina Pliskova [8] | 3-6,2-6 | |
| Australian Open Women | 01/11 03:45 | 46 | [179] Jamie Loeb v Karolina Muchova [141] | 4-6,1-6 | |
| Australian Open Women | 01/10 01:35 | 45 | [184] Liudmila Samsonova v Karolina Muchova [141] | 4-6,0-6 | |
| Australian Open Women | 01/08 23:00 | 44 | [172] Arina Rodionova v Karolina Muchova [141] | 2-6,4-6 | |
| WTA Brisbane | 12/30 02:00 | 54 | [144] Karolina Muchova v Anastasia Potapova [93] | 6-1,6-7,0-6 | |
| WTA Brisbane | 12/29 00:00 | 46 | [58] Dayana Yastremska v Karolina Muchova [144] | Retired | |
| WTA Brisbane | 12/28 02:05 | 45 | [237] Lizette Cabrera v Karolina Muchova [144] | 2-6,2-6 | |
| WTA Luxembourg | 10/14 10:40 | 46 | [148] Karolina Muchova v Jana Fett [173] | Walkover | |
| WTA Luxembourg | 10/13 16:30 | 45 | [89] Heather Watson v Karolina Muchova [148] | 2-6,6-2,4-6 | |
| US Open Women | 09/01 00:15 | 25 | [202] Karolina Muchova v Ashleigh Barty [17] | 3-6,4-6 | |
| US Open Women | 08/30 02:30 | 24 | [12] Garbine Muguruza v Karolina Muchova [202] | 6-3,4-6,4-6 | |
| US Open Women | 08/27 19:35 | 23 | [202] Karolina Muchova v Dayana Yastremska [98] | 6-4,6-2 | |
| US Open Women | 08/24 18:05 | 46 | [202] Karolina Muchova v Francoise Abanda [210] | 6-4,6-2 | |
| US Open Women | 08/23 21:30 | 45 | [202] Karolina Muchova v Jasmine Paolini [230] | 7-5,6-2 | |
| US Open Women | 08/22 19:45 | 44 | [107] Vitalia Diatchenko v Karolina Muchova [202] | 1-6,7-6,1-6 |