| WTA Doha | 02/14 12:30 | 27 | [7] Elina Svitolina v Karolina Muchova [132] | 6-4,6-2 | |
| WTA Doha | 02/13 12:30 | 26 | [31] Su-Wei Hsieh v Karolina Muchova [132] | 2-6,4-6 | |
| WTA Doha | 02/12 14:45 | 25 | [132] Karolina Muchova v Samantha Stosur [73] | 6-4,6-2 | |
| WTA Doha | 02/12 13:30 | - | Karolina Muchova v Caroline Wozniacki | Cancelled | |
| WTA Doha | 02/11 12:30 | 54 | [167] Liudmila Samsonova v Karolina Muchova [132] | 1-6,6-3,1-6 | |
| WTA Doha | 02/10 12:30 | 46 | [133] Karolina Muchova v Kristyna Pliskova [90] | 6-3,4-6,6-4 | |
| WTA Doha | 02/09 08:00 | 45 | Mubaraka Al-Naimi v Karolina Muchova | 0-6,0-6 | |
| Australian Open Women | 01/15 00:00 | 23 | [139] Karolina Muchova v Karolina Pliskova [8] | 3-6,2-6 | |
| Australian Open Women | 01/11 03:45 | 46 | [179] Jamie Loeb v Karolina Muchova [141] | 4-6,1-6 | |
| Australian Open Women | 01/10 01:35 | 45 | [184] Liudmila Samsonova v Karolina Muchova [141] | 4-6,0-6 | |
| Australian Open Women | 01/08 23:00 | 44 | [172] Arina Rodionova v Karolina Muchova [141] | 2-6,4-6 | |
| WTA Brisbane | 12/30 02:00 | 54 | [144] Karolina Muchova v Anastasia Potapova [93] | 6-1,6-7,0-6 | |
| WTA Brisbane | 12/29 00:00 | 46 | [58] Dayana Yastremska v Karolina Muchova [144] | 2-6,1-5 | |
| WTA Brisbane | 12/28 02:05 | 45 | [237] Lizette Cabrera v Karolina Muchova [144] | 2-6,2-6 | |
| WTA Luxembourg | 10/14 10:40 | - | [148] Karolina Muchova v Jana Fett [173] | Walkover | |
| WTA Luxembourg | 10/13 16:30 | 45 | [89] Heather Watson v Karolina Muchova [148] | 2-6,6-2,4-6 | |
| US Open Women | 09/01 00:15 | - | [202] Karolina Muchova v Ashleigh Barty [17] | 3-6,4-6 | |
| US Open Women | 08/30 02:30 | - | [12] Garbine Muguruza v Karolina Muchova [202] | 6-3,4-6,4-6 | |
| US Open Women | 08/27 19:35 | - | [202] Karolina Muchova v Dayana Yastremska [98] | 6-4,6-2 | |
| US Open Women | 08/24 18:05 | - | [202] Karolina Muchova v Francoise Abanda [210] | 6-4,6-2 | |
| US Open Women | 08/23 21:30 | - | [202] Karolina Muchova v Jasmine Paolini [230] | 7-5,6-2 | |
| US Open Women | 08/22 19:45 | - | [107] Vitalia Diatchenko v Karolina Muchova [202] | 1-6,7-6,1-6 | |
| ITF Women Prague | 07/27 13:00 | - | Karolina Muchova v Tamara Korpatsch | away | |
| ITF Women Prague | 07/26 11:05 | - | [183] Barbora Krejcikova v Karolina Muchova [179] | 4-6,3-6 | |
| ITF Women Prague | 07/25 12:10 | - | [179] Karolina Muchova v Michaela Honcova [251] | 1-6,7-5,6-2 | |
| ITF Women Olomouc | 07/22 08:30 | - | [218] Karolina Muchova v Fiona Ferro [157] | 4-6,4-6 | |
| ITF Women Olomouc | 07/21 11:20 | - | [245] Tereza Mrdeza v Karolina Muchova [218] | 6-4,5-7,5-7 | |
| ITF Women Olomouc | 07/20 12:50 | - | [475] Maja Chwalinska v Karolina Muchova [218] | 3-6,0-6 | |
| ITF Women Olomouc | 07/19 09:00 | - | [218] Karolina Muchova v Michaela Honcova [221] | 6-4,6-4 | |
| ITF Women Olomouc | 07/17 09:50 | - | Karolina Muchova v Magdalena Pantuckova | 6-0,6-0 |