Avispas de Santiago de Cuba (English: Santiago de Cuba Wasps) is a baseball team in the Cuban National Series based in Estadio Guillermón Moncada in Santiago de Cuba. The Avispas (Wasps) are historically one of the most successful teams in the National Series, the main domestic competition in post-revolutionary Cuban baseball. The team is similar to the Boston Red Sox in MLB in the sense that they have fans all over the country (especially in the east), and are the eternal rivals of Industriales, the New York Yankees of Cuban baseball. The traditional rivalry on the baseball diamond also represents the rivalry between the two cities (La Habana and Santiago de Cuba) dating back to the era when Cuba was a colony of Spain two centuries ago. The Super Classic of the Cuban National Series between EB Santiago de Cuba and Industriales takes place six times per season.

The Avispas have won eight Cuban National Series championships, including three straight titles during the 1998-99, 1999-2000, and 2000-01 seasons. Santiago's latest Cuban National Series championship came in the 2007-2008 season, defeating Pinar del Rio in a 4 game sweep.

Santiago de Cuba has sent one player to the 2006 World Baseball Classic, pitcher Ormari Romero; and four players to the 2009 World Baseball Classic: Luis Miguel Navas, Norge Luis Vera, Hector Olivera and Rolando Meriño. Two Avispas have gone to the Olympic Games, Rey Isaac in 1996, and Danny Betancourt in 2004. In each year, the Cuban team won gold.

Santiago de Cuba is a professional baseball team based in the city of Santiago de Cuba, Cuba. The team was founded in 1961 and has since become one of the most successful teams in Cuban baseball history. The team plays in the Cuban National Series, which is the top level of baseball in Cuba.

Santiago de Cuba is known for its strong pitching and solid defense. The team has produced many talented players over the years, including several who have gone on to play in Major League Baseball in the United States. The team's home stadium is Estadio Guillermón Moncada, which has a seating capacity of over 20,000.

The team's colors are red and white, and its logo features a stylized "S" with a baseball in the center. Santiago de Cuba has won the Cuban National Series eight times, most recently in 2015. The team has also won several international tournaments, including the Caribbean Series and the Pan American Games.

Santiago de Cuba has a passionate fan base and is known for its lively and energetic atmosphere at home games. The team's success and popularity have made it a symbol of pride for the city and the entire region of eastern Cuba.