[6] Alexander Zverev 7-6,4-6,1-10 John Isner [20] 2019-09-21 11:00
Stadium: Palexpo Round: 44 Ground: Hardcourt indoor
Head to Head
| ATP World Tour Finals | 2018/11/16 14:00 | Alexander Zverev v John Isner | 7-6,6-3 |
| Laver Cup | 2018/09/22 18:00 | Alexander Zverev v John Isner | 3-6,7-6,10-7 |
| ATP Madrid | 2018/05/11 20:00 | John Isner v Alexander Zverev | 4-6,5-7 |
| ATP Miami | 2018/04/01 17:00 | Alexander Zverev v John Isner | 7-6,4-6,4-6 |
| ATP Rome | 2017/05/20 13:00 | Alexander Zverev v John Isner | 6-4,6-7,6-1 |
| ATP Miami | 2017/03/27 20:40 | John Isner v Alexander Zverev | 7-6,6-7,6-7 |
| ATP Shanghai | 2016/10/10 07:10 | Alexander Zverev v John Isner | 6-4,6-2 |
Home History
| US Open | 2019/09/02 17:55 | Alexander Zverev v Diego Schwartzman | 6-3,2-6,4-6,3-6 |
| US Open | 2019/08/31 18:25 | Alexander Zverev v Aljaz Bedene | 6-7,7-6,6-3,7-6 |
| US Open | 2019/08/29 16:00 | Alexander Zverev v Frances Tiafoe | 6-3,3-6,6-2,2-6,6-3 |
| US Open | 2019/08/27 18:15 | Alexander Zverev v Radu Albot | 6-1,6-3,3-6,4-6,6-2 |
| ATP Cincinnati | 2019/08/14 19:05 | Alexander Zverev v Miomir Kecmanovic | 7-6,2-6,4-6 |
| ATP Montreal | 2019/08/09 18:00 | Karen Khachanov v Alexander Zverev | 6-3,6-3 |
| ATP Montreal | 2019/08/08 18:25 | Nikoloz Basilashvili v Alexander Zverev | 5-7,7-5,6-7 |
| ATP Montreal | 2019/08/07 01:25 | Cameron Norrie v Alexander Zverev | 6-7,4-6 |
Away History
| US Open | 2019/08/31 18:40 | John Isner v Marin Cilic | 5-7,6-3,6-7,4-6 |
| US Open | 2019/08/29 18:30 | John Isner v Jan-Lennard Struff | 6-3,7-6,7-6 |
| US Open | 2019/08/27 17:25 | John Isner v Guillermo Garcia-Lopez | 6-3,6-4,6-4 |
| ATP Cincinnati | 2019/08/14 02:30 | Pablo Carreno Busta v John Isner | 6-4,6-7,7-6 |
| ATP Cincinnati | 2019/08/11 23:00 | Dusan Lajovic v John Isner | 6-7,6-1,5-7 |
| ATP Montreal | 2019/08/07 21:15 | Cristian Garin v John Isner | 6-3,6-4 |
| ATP Montreal | 2019/08/06 16:00 | Jordan Thompson v John Isner | 6-3,3-6,6-7 |
| ATP Washington | 2019/08/02 00:00 | Benoit Paire v John Isner | 7-6,6-3 |
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