Stadium: Macpherson Stadium Round: 1
| USA USL W-League Women | 2022/05/18 23:00 | Charlotte Independence Women v North Carolina Fusion Women | L | 4-0 |
| USA USL W-League Women | 2022/06/20 23:00 | North Carolina Fusion Women v Wake FC Women | L | 0-4 |
| USA USL W-League Women | 2022/06/17 23:00 | North Carolina Fusion Women v North Carolina Courage Women U23 | L | 0-4 |
| USA USL W-League Women | 2022/06/14 23:00 | North Carolina Fusion Women v Asheville City SC Women | L | 1-3 |
| USA USL W-League Women | 2022/06/09 23:00 | North Carolina Fusion Women v Wake FC Women | L | 0-3 |
| USA USL W-League Women | 2022/06/07 23:00 | Greenville Liberty Women v North Carolina Fusion Women | L | 3-0 |
| USA USL W-League Women | 2022/06/01 22:00 | North Carolina Courage Women U23 v North Carolina Fusion Women | L | 5-1 |
| USA USL W-League Women | 2022/05/25 23:00 | North Carolina Fusion Women v Greenville Liberty Women | L | 1-2 |
| USA USL W-League Women | 2022/05/20 23:30 | Asheville City SC Women v North Carolina Fusion Women | L | 3-0 |
| USA USL W-League Women | 2022/06/25 22:00 | Charlotte Independence Women v Wake FC Women | L | 0-4 |
| USA USL W-League Women | 2022/06/21 21:00 | Asheville City SC Women v Charlotte Independence Women | D | 1-1 |
| USA USL W-League Women | 2022/06/18 22:00 | Charlotte Independence Women v Asheville City SC Women | D | 1-1 |
| USA USL W-League Women | 2022/06/14 23:00 | Charlotte Independence Women v North Carolina Courage Women U23 | L | 0-2 |
| USA USL W-League Women | 2022/06/11 22:00 | Greenville Liberty Women v Charlotte Independence Women | L | 2-1 |
| USA USL W-League Women | 2022/06/01 22:30 | Wake FC Women v Charlotte Independence Women | W | 1-2 |
| USA USL W-League Women | 2022/05/28 20:00 | North Carolina Courage Women U23 v Charlotte Independence Women | D | 1-1 |
| USA USL W-League Women | 2022/05/18 23:00 | Charlotte Independence Women v North Carolina Fusion Women | W | 4-0 |