[10] South Alabama 20-17 UL Lafayette [11] 2022-10-01 21:00
Stadium: Cajun Field Round: 1
Home Manager: Michael Desormeaux Away Manager: Kane Wommack
Head to Head
| NCAAF | 2021/10/03 00:00 | Lafayette v South Alabama | L | 20-18 |
| NCAAF | 2020/11/14 19:00 | South Alabama v Lafayette | L | 10-38 |
| NCAAF | 2019/11/16 22:00 | Lafayette v South Alabama | L | 37-27 |
| NCAAF | 2018/11/17 22:00 | South Alabama v Lafayette | L | 38-48 |
| NCAAF | 2017/11/04 20:00 | Lafayette v South Alabama | L | 19-14 |
| NCAAF | 2016/09/17 23:00 | Lafayette v South Alabama | L | 28-23 |
| NCAAF | 2015/11/13 00:30 | South Alabama v Lafayette | W | 32-25 |
| NCAAF | 2014/11/01 21:00 | Lafayette v South Alabama | L | 19-9 |
Home History
| NCAAF | 2022/09/24 23:00 | Louisiana Tech v South Alabama | W | 14-38 |
| NCAAF | 2022/09/17 18:00 | South Alabama v UCLA | L | 31-32 |
| NCAAF | 2022/09/10 17:00 | South Alabama v Central Michigan | W | 38-24 |
| NCAAF | 2022/09/03 21:00 | Nicholls State v South Alabama | W | 7-48 |
| NCAAF | 2021/11/26 20:30 | Coastal Carolina v South Alabama | L | 27-21 |
| NCAAF | 2021/11/21 00:30 | South Alabama v Tennessee | L | 14-60 |
| NCAAF | 2021/11/13 19:30 | South Alabama v Appalachian St | L | 7-31 |
| NCAAF | 2021/11/06 19:30 | South Alabama v Troy | L | 24-31 |
Away History
| NCAAF | 2022/10/01 19:30 | Lafayette v Bucknell | W | 24-14 |
| NCAAF | 2022/09/25 00:00 | Lafayette v UL Monroe | L | 17-21 |
| NCAAF | 2022/09/24 17:00 | Lafayette v Pennsylvania | L | 0-12 |
| NCAAF | 2022/09/17 23:30 | Lafayette v Rice | L | 21-33 |
| NCAAF | 2022/09/17 19:30 | William & Mary v Lafayette | L | 34-7 |
| NCAAF | 2022/09/10 23:00 | Eastern Michigan v Lafayette | W | 21-49 |
| NCAAF | 2022/09/10 18:00 | Lafayette v Temple | L | 14-30 |
| NCAAF | 2022/09/03 23:00 | SE Louisiana v Lafayette | W | 7-24 |
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