[43] John Isner 7-6,6-7,2-6,2-6 Adrian Mannarino [45] 2023-01-17 10:50
Stadium: Court 3 Round: 23 Ground: Hardcourt outdoor
Head to Head
| ATP Acapulco | 2019/02/26 22:00 | John Isner v Adrian Mannarino | 6-3,4-6,6-3 |
| ATP Delray Beach | 2019/02/22 19:30 | Adrian Mannarino v John Isner | 6-7,4-6 |
| Challenger Shanghai | 2015/10/12 07:30 | Adrian Mannarino v John Isner | 1-6,2-6 |
| ATP Madrid | 2015/05/04 11:00 | Adrian Mannarino v John Isner | 6-7,4-6 |
Home History
| ATP Auckland | 2023/01/09 23:00 | Gregoire Barrere v John Isner | 6-7,7-6,6-3 |
| ATP Paris | 2022/11/01 10:00 | John Isner v Andrey Rublev | 2-6,3-6 |
| ATP Paris | 2022/10/31 10:00 | John Isner v Oscar Otte | 6-4,7-6 |
| US Open | 2022/08/30 16:20 | John Isner v Federico Delbonis | 6-3,6-1,7-5 |
| ATP Cincinnati | 2022/08/19 19:00 | Stefanos Tsitsipas v John Isner | 7-6,5-7,6-3 |
| ATP Cincinnati | 2022/08/18 20:00 | Sebastian Korda v John Isner | 6-7,6-1,6-7 |
| ATP Cincinnati | 2022/08/17 16:35 | John Isner v Hubert Hurkacz | 7-6,6-7,6-2 |
| ATP Cincinnati | 2022/08/15 18:00 | Benjamin Bonzi v John Isner | 6-7,6-3,6-7 |
Away History
| ATP Auckland | 2023/01/09 07:40 | Adrian Mannarino v Jeffrey John Wolf | 4-6,6-7 |
| United Cup | 2023/01/03 10:40 | Adrian Mannarino v Borna Gojo | 6-7,6-3,6-7 |
| United Cup | 2022/12/30 11:00 | Adrian Mannarino v Federico Coria | 6-1,6-0 |
| ATP Paris | 2022/11/01 13:15 | Hubert Hurkacz v Adrian Mannarino | 7-6,6-4 |
| ATP Basel | 2022/10/25 15:00 | Botic Van De Zandschulp v Adrian Mannarino | 6-4,4-6,6-4 |
| ATP Naples | 2022/10/18 10:00 | Adrian Mannarino v Pedro Cachin | 1-6,6-3,4-6 |
| ATP Astana | 2022/10/07 06:00 | Adrian Mannarino v Andrey Rublev | 1-6,2-6 |
| ATP Astana | 2022/10/05 09:10 | David Goffin v Adrian Mannarino | 6-3,1-6,5-7 |
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