Louisville 23-54 Syracuse 2018-11-10 00:00
Stadium: JMA Wireless Dome Round: 1
Home Manager: Dino Babers Away Manager: Bobby Petrino
Head to Head
| NCAAF | 2017/11/18 20:30 | Syracuse v Louisville | W | 10-56 |
| NCAAF | 2016/09/10 00:00 | Louisville v Syracuse | W | 62-28 |
| NCAAF | 2015/11/07 17:30 | Louisville v Syracuse | W | 41-17 |
| NCAAF | 2014/10/03 23:00 | Syracuse v Louisville | W | 6-28 |
| NCAAF | 2012/11/10 12:00 | Syracuse v Louisville | L | 45-26 |
| NCAAF | 2011/10/29 12:00 | Louisville v Syracuse | W | 27-10 |
| NCAAF | 2010/11/06 12:00 | Syracuse v Louisville | W | 20-28 |
| NCAAF | 2009/11/14 12:00 | Louisville v Syracuse | W | 10-9 |
Home History
| NCAAF | 2018/11/03 16:00 | Louisville v Clemson | L | 16-77 |
| NCAAF | 2018/10/27 16:00 | Wake Forest v Louisville | L | 56-35 |
| NCAAF | 2018/10/13 16:30 | Louisville v Boston College | L | 20-38 |
| NCAAF | 2018/10/05 23:00 | Georgia Tech v Louisville | L | 66-31 |
| NCAAF | 2018/09/29 19:30 | Florida State v Louisville | L | 28-24 |
| NCAAF | 2018/09/22 16:30 | Louisville v Virginia | L | 3-27 |
| NCAAF | 2018/09/15 23:30 | Western Kentucky v Louisville | W | 17-20 |
| NCAAF | 2018/09/08 23:00 | Indiana State v Louisville | W | 7-31 |
Away History
| NCAAF | 2018/11/03 16:00 | Syracuse v Wake Forest | W | 41-24 |
| NCAAF | 2018/10/27 23:00 | NC State v Syracuse | W | 41-51 |
| NCAAF | 2018/10/20 16:20 | North Carolina v Syracuse | W | 37-40 |
| NCAAF | 2018/10/06 16:20 | Syracuse v Pittsburgh | L | 37-44 |
| NCAAF | 2018/09/29 16:00 | Syracuse v Clemson | L | 23-27 |
| NCAAF | 2018/09/22 20:00 | Connecticut v Syracuse | W | 21-51 |
| NCAAF | 2018/09/15 16:00 | Florida State v Syracuse | W | 7-30 |
| NCAAF | 2018/09/08 19:30 | Wagner v Syracuse | W | 10-62 |
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