[15] Pachuca 1-0 Santos Laguna [5] 2021-04-27 02:00
Stadium: Estadio Hidalgo Round: 16
Referee: Diego Montano Robles Home Manager: Paulo Pezzolano Away Manager: Guillermo Almada
Head to Head
| Mexico Liga MX | 2020/11/22 01:00 | Santos Laguna v Pachuca | W | 0-3 |
| Mexico Liga MX | 2020/10/19 00:06 | Santos Laguna v Pachuca | D | 1-1 |
| Mexico Liga MX | 2020/03/08 01:00 | Pachuca v Santos Laguna | W | 1-0 |
| Mexico Liga MX | 2019/09/15 23:45 | Santos Laguna v Pachuca | D | 2-2 |
| Mexico Liga MX | 2019/04/07 23:06 | Santos Laguna v Pachuca | D | 0-0 |
| Mexico Liga MX | 2018/10/21 00:00 | Pachuca v Santos Laguna | D | 1-1 |
| Mexico Cup | 2018/08/30 00:00 | Santos Laguna v Pachuca | D | 0-0 |
| Mexico Cup | 2018/08/01 02:00 | Pachuca v Santos Laguna | W | 2-0 |
Home History
| Mexico Liga MX | 2021/04/19 02:06 | Monterrey v Pachuca | W | 0-1 |
| Mexico Liga MX | 2021/04/13 02:00 | Pachuca v Puebla | L | 1-3 |
| Mexico Liga MX | 2021/04/04 17:00 | Unam Pumas v Pachuca | D | 2-2 |
| Mexico Liga MX | 2021/03/19 02:00 | Pachuca v Tigres UANL | W | 1-0 |
| Mexico Liga MX | 2021/03/14 18:00 | Toluca v Pachuca | W | 0-2 |
| Mexico Liga MX | 2021/03/09 03:00 | Pachuca v Tijuana | W | 2-1 |
| Mexico Liga MX | 2021/03/05 01:00 | Necaxa v Pachuca | D | 2-2 |
| Mexico Liga MX | 2021/02/28 01:00 | Club America v Pachuca | L | 2-0 |
Away History
| Mexico Liga MX | 2021/04/19 00:00 | Santos Laguna v Toluca | W | 3-1 |
| Mexico Liga MX | 2021/04/12 00:00 | Queretaro v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/04/04 22:00 | Chivas Guadalajara v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/03/22 01:06 | Santos Laguna v Leon | L | 1-2 |
| Mexico Liga MX | 2021/03/14 03:05 | Tijuana v Santos Laguna | W | 0-1 |
| Mexico Liga MX | 2021/03/08 01:06 | Santos Laguna v Necaxa | W | 3-1 |
| Mexico Liga MX | 2021/03/05 03:00 | Unam Pumas v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/03/01 01:06 | Santos Laguna v Juarez FC | W | 3-2 |
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