[31] BUF Sabres 2-5 PIT Penguins [11] 2021-03-25 00:00
Stadium: PPG Paints Arena
Home Manager: Mike Sullivan Away Manager: Don Granato
Head to Head
| NHL | 2021/03/14 00:00 | PIT Penguins v BUF Sabres | L | 3-0 |
| NHL | 2021/03/12 00:00 | PIT Penguins v BUF Sabres | L | 5-2 |
| NHL | 2020/03/06 00:00 | PIT Penguins v BUF Sabres | L | 4-2 |
| NHL | 2020/02/22 18:00 | BUF Sabres v PIT Penguins | W | 5-2 |
| NHL | 2019/10/03 23:00 | BUF Sabres v PIT Penguins | W | 3-1 |
| NHL Pre-Season | 2019/09/28 20:00 | BUF Sabres v PIT Penguins | W | 3-2 |
| NHL Pre-Season | 2019/09/16 23:00 | PIT Penguins v BUF Sabres | W | 4-5 |
| NHL | 2019/03/14 23:00 | PIT Penguins v BUF Sabres | L | 5-0 |
Home History
| NHL | 2021/03/22 23:00 | BUF Sabres v NY Rangers | L | 3-5 |
| NHL | 2021/03/18 23:00 | BOS Bruins v BUF Sabres | L | 4-1 |
| NHL | 2021/03/16 23:00 | BUF Sabres v NJ Devils | L | 2-3 |
| NHL | 2021/03/15 23:00 | WAS Capitals v BUF Sabres | L | 6-0 |
| NHL | 2021/03/14 00:00 | PIT Penguins v BUF Sabres | L | 3-0 |
| NHL | 2021/03/12 00:00 | PIT Penguins v BUF Sabres | L | 5-2 |
| NHL | 2021/03/10 00:00 | BUF Sabres v PHI Flyers | L | 4-5 |
| NHL | 2021/03/07 17:00 | BUF Sabres v NY Islanders | L | 2-5 |
Away History
| NHL | 2021/03/21 17:00 | NJ Devils v PIT Penguins | L | 2-1 |
| NHL | 2021/03/20 17:00 | PIT Penguins v NJ Devils | W | 3-1 |
| NHL | 2021/03/18 23:00 | PIT Penguins v NJ Devils | L | 2-3 |
| NHL | 2021/03/16 23:00 | BOS Bruins v PIT Penguins | L | 2-1 |
| NHL | 2021/03/15 23:00 | BOS Bruins v PIT Penguins | W | 1-4 |
| NHL | 2021/03/14 00:00 | PIT Penguins v BUF Sabres | W | 3-0 |
| NHL | 2021/03/12 00:00 | PIT Penguins v BUF Sabres | W | 5-2 |
| NHL | 2021/03/09 23:00 | NY Rangers v PIT Penguins | W | 2-4 |
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