Head to Head
| NFL Preseason | 2019/08/16 23:00 | BUF Bills v CAR Panthers | W | 27-14 |
| NFL Preseason | 2018/08/09 23:00 | CAR Panthers v BUF Bills | L | 28-23 |
| NFL | 2018/02/02 09:34 | BUF Bills v CAR Panthers | L | 19-25 |
| NFL | 2017/09/17 17:00 | BUF Bills v CAR Panthers | L | 3-9 |
Home History
| NFL | 2021/01/24 23:40 | BUF Bills v KC Chiefs | L | 24-38 |
| NFL | 2021/01/17 01:15 | BAL Ravens v BUF Bills | W | 3-17 |
| NFL | 2021/01/09 18:05 | IND Colts v BUF Bills | W | 24-27 |
| NFL | 2021/01/03 18:00 | MIA Dolphins v BUF Bills | W | 26-56 |
| NFL | 2020/12/29 01:15 | BUF Bills v NE Patriots | W | 38-9 |
| NFL | 2020/12/19 21:30 | BUF Bills v DEN Broncos | W | 48-19 |
| NFL | 2020/12/14 01:20 | PIT Steelers v BUF Bills | W | 15-26 |
| NFL | 2020/12/08 01:15 | BUF Bills v SF 49ers | W | 34-24 |
Away History
| NFL | 2021/01/03 21:25 | NO Saints v CAR Panthers | L | 33-7 |
| NFL | 2020/12/27 21:05 | CAR Panthers v WAS Commanders | W | 20-13 |
| NFL | 2020/12/20 01:15 | CAR Panthers v GB Packers | L | 16-24 |
| NFL | 2020/12/13 18:00 | DEN Broncos v CAR Panthers | L | 32-27 |
| NFL | 2020/11/29 18:00 | CAR Panthers v MIN Vikings | L | 27-28 |
| NFL | 2020/11/22 18:00 | DET Lions v CAR Panthers | W | 0-20 |
| NFL | 2020/11/15 18:00 | TB Buccaneers v CAR Panthers | L | 46-23 |
| NFL | 2020/11/08 18:00 | CAR Panthers v KC Chiefs | L | 31-33 |
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