Stadium: Roy Stewart Stadium Round: 1
Home Manager: Dean Hood Away Manager: Tom Matukewicz
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | L | 32-31 |
| NCAAF | 2021/03/07 20:00 | Murray State v SE Missouri St | L | 24-21 |
| NCAAF | 2019/11/23 19:00 | Murray State v SE Missouri St | W | 24-31 |
| NCAAF FCS | 2018/11/10 17:00 | SE Missouri St v Murray State | L | 38-40 |
| NCAAF | 2017/11/18 19:00 | SE Missouri St v Murray State | W | 21-10 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | W | 15-38 |
| NCAAF | 2021/10/23 19:00 | SE Missouri St v Tennessee Martin | L | 30-38 |
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | L | 32-31 |
| NCAAF | 2021/10/09 20:00 | SE Missouri St v Austin Peay | W | 30-14 |
| NCAAF | 2021/10/02 18:30 | SE Missouri St v Tennessee Tech | L | 17-28 |
| NCAAF | 2021/09/25 19:00 | Tennessee State v SE Missouri St | W | 14-47 |
| NCAAF | 2021/09/18 16:00 | SE Missouri St v Missouri | L | 28-59 |
| NCAAF | 2021/09/11 23:00 | SE Missouri St v Sam Houston State | L | 14-52 |
| NCAAF | 2021/11/06 18:00 | Tennessee Tech v Murray State | W | 27-32 |
| NCAAF | 2021/10/30 22:00 | Murray State v Tennessee State | L | 21-27 |
| NCAAF | 2021/10/23 19:00 | Austin Peay v Murray State | L | 47-6 |
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | W | 32-31 |
| NCAAF | 2021/10/09 19:00 | Murray State v Tennessee Martin | L | 24-48 |
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | W | 6-22 |
| NCAAF | 2021/09/18 21:00 | Murray State v Bowling Green | L | 10-27 |
| NCAAF | 2021/09/11 19:30 | Murray State v Cincinnati | L | 7-42 |