Stadium: Mitchell Center
Home Manager: Richie Riley Away Manager: Brian Barone
| NCAAB | 2021/12/19 19:00 | William Woods v SIU Edwardsville | W | 29-84 |
| NCAAB | 2021/12/12 20:00 | Kansas City v SIU Edwardsville | W | 56-60 |
| NCAAB | 2021/12/09 01:00 | IPFW v SIU Edwardsville | W | 59-80 |
| NCAAB | 2021/12/04 20:00 | SIU Edwardsville v Bradley | L | 55-80 |
| NCAAB | 2021/12/01 01:00 | SIU Edwardsville v Nebraska Omaha | W | 75-65 |
| NCAAB | 2021/11/27 23:00 | SIU Edwardsville v Creighton | L | 65-70 |
| NCAAB | 2021/11/21 18:00 | SIU Edwardsville v St. Thomas (MN) | L | 73-86 |
| NCAAB | 2021/11/20 19:00 | SIU Edwardsville v Youngstown State | W | 69-66 |
| NCAAB | 2021/12/18 01:00 | South Alabama v Tarleton State | L | 52-65 |
| NCAAB | 2021/12/15 01:00 | Tarleton State v South Alabama | W | 62-69 |
| NCAAB | 2021/12/05 01:30 | South Alabama v Jacksonville St | W | 74-64 |
| NCAAB | 2021/12/02 01:00 | Southern Miss v South Alabama | W | 55-85 |
| NCAAB | 2021/11/30 01:00 | South Alabama v Texas A&M Commerce | W | 69-66 |
| NCAAB | 2021/11/26 23:00 | South Alabama v Hawaii | W | 72-69 |
| NCAAB | 2021/11/25 18:30 | South Alabama v San Diego | W | 68-67 |
| NCAAB | 2021/11/23 01:00 | South Alabama v William Carey | W | 96-53 |