| Spain Segunda División | 2021/12/04 17:00 | Real Betis B v Ciudad de Mostoles | W | 8-4 |
| Spain Segunda División | 2021/11/27 17:00 | Union Africa Ceuti v Real Betis B | L | 4-2 |
| Spain Segunda División | 2021/11/20 15:00 | Real Betis B v Nitida Alzira FS | L | 1-2 |
| Spain Segunda División | 2021/11/13 16:00 | Calvia v Real Betis B | W | 3-6 |
| Spain Segunda División | 2021/11/07 15:00 | Real Betis B v Barcelona B | L | 3-4 |
| Spain Segunda División | 2021/10/30 15:30 | Bisontes Castellon v Real Betis B | L | 5-3 |
| Spain Segunda División | 2021/10/23 16:00 | FS Talavera v Real Betis B | L | 7-1 |
| Spain Segunda División | 2021/10/17 10:30 | Real Betis B v At. Benavente | L | 1-3 |
| Spain Segunda División | 2021/12/08 16:00 | Inter Movistar FS B v FS Talavera | W | 5-3 |
| Spain Segunda División | 2021/12/04 18:00 | At. Benavente v Inter Movistar FS B | D | 2-2 |
| Spain Segunda División | 2021/11/28 11:45 | Inter Movistar FS B v Leganes | W | 3-2 |
| Spain Segunda División | 2021/11/20 17:00 | O Parrulo Ferrol v Inter Movistar FS B | D | 2-2 |
| Spain Segunda División | 2021/11/14 11:45 | Inter Movistar FS B v Peniscola Bod. Dunviro | L | 4-5 |
| Spain Segunda División | 2021/11/06 17:00 | El Ejido v Inter Movistar FS B | L | 4-0 |
| Spain Segunda División | 2021/10/30 14:00 | Inter Movistar FS B v UMA Antequera | L | 1-5 |
| Spain Segunda División | 2021/10/23 16:30 | Colo Colo Zaragoza v Inter Movistar FS B | D | 2-2 |