Stadium: Quadra Central Round: 26 Ground: Clay
| Challenger Florianopolis | 2021/12/07 16:50 | Juan Pablo Ficovich v Nicolas Barrientos | 3-6,0-6 |
| Challenger Florianopolis | 2021/12/06 14:20 | Alejandro Gomez v Nicolas Barrientos | 4-6,2-6 |
| Challenger Florianopolis | 2021/12/05 15:25 | Victor Tosetto v Nicolas Barrientos | 1-6,1-6 |
| Challenger Guayaquil | 2021/11/01 16:00 | Nicolas Alvarez v Nicolas Barrientos | 2-6,6-4,6-4 |
| Challenger Guayaquil | 2021/10/31 18:30 | Nicolas Barrientos v Alejandro Gomez | 7-6,6-4 |
| Challenger Bogota | 2021/10/23 15:00 | Gerald Melzer v Nicolas Barrientos | 6-2,6-7,6-1 |
| Challenger Bogota | 2021/10/22 15:00 | Nicolas Barrientos v Oriol Roca Batalla | 6-3,7-5 |
| Challenger Bogota | 2021/10/21 15:00 | Enzo Couacaud v Nicolas Barrientos | 3-6,4-6 |
| Challenger Florianopolis | 2021/12/07 16:05 | Pedro Boscardin Dias v Gonzalo Villanueva | 6-4,5-7,2-6 |
| Challenger Sao Paulo | 2021/11/30 16:55 | Facundo Diaz Acosta v Gonzalo Villanueva | 7-5,6-1 |
| Challenger Sao Paulo | 2021/11/29 15:05 | Gonzalo Villanueva v Alejandro Gomez | 6-4,7-6 |
| Challenger Sao Paulo | 2021/11/28 13:00 | Gonzalo Villanueva v Tomas Lipovsek Puches | 3-6,6-3,6-1 |
| Challenger Brasilia | 2021/11/21 14:35 | Gonzalo Villanueva v Luca Castelnuovo | 6-7,6-3,3-6 |
| Challenger Campinas | 2021/11/14 16:00 | Hernan Casanova v Gonzalo Villanueva | 7-6,4-6,7-5 |
| Challenger Montevideo | 2021/11/09 16:00 | Facundo Bagnis v Gonzalo Villanueva | 6-1,7-6 |
| Challenger Montevideo | 2021/11/08 16:30 | Tomas Lipovsek Puches v Gonzalo Villanueva | 3-6,2-6 |