[2] PIT Penguins 3-4 BUF Sabres [12] 2022-03-23 23:30
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Mike Sullivan
Head to Head
| NHL | 2021/12/18 00:00 | BUF Sabres v PIT Penguins | W | 2-3 |
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | L | 2-1 |
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | W | 4-5 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | W | 2-1 |
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | W | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | W | 4-8 |
| NHL | 2021/04/18 19:00 | PIT Penguins v BUF Sabres | L | 2-4 |
| NHL | 2021/04/17 19:00 | PIT Penguins v BUF Sabres | W | 3-2 |
Home History
| NHL | 2022/03/22 23:00 | CLB Blue Jackets v PIT Penguins | W | 1-5 |
| NHL | 2022/03/19 21:00 | PIT Penguins v ARZ Coyotes | W | 4-1 |
| NHL | 2022/03/18 00:00 | PIT Penguins v STL Blues | W | 3-2 |
| NHL | 2022/03/16 00:00 | PIT Penguins v NAS Predators | L | 1-4 |
| NHL | 2022/03/13 17:00 | CAR Hurricanes v PIT Penguins | W | 2-4 |
| NHL | 2022/03/12 00:00 | VGS Golden Knights v PIT Penguins | W | 2-5 |
| NHL | 2022/03/09 00:00 | FLA Panthers v PIT Penguins | L | 4-3 |
| NHL | 2022/03/05 00:00 | PIT Penguins v CAR Hurricanes | L | 2-3 |
Away History
| NHL | 2022/03/21 02:00 | BUF Sabres v VAN Canucks | W | 3-2 |
| NHL | 2022/03/19 01:00 | BUF Sabres v CAL Flames | W | 1-0 |
| NHL | 2022/03/18 01:00 | BUF Sabres v EDM Oilers | L | 1-6 |
| NHL | 2022/03/13 20:00 | TOR Maple Leafs v BUF Sabres | W | 2-5 |
| NHL | 2022/03/11 00:00 | VGS Golden Knights v BUF Sabres | W | 1-3 |
| NHL | 2022/03/08 00:00 | FLA Panthers v BUF Sabres | L | 6-1 |
| NHL | 2022/03/06 18:00 | LA Kings v BUF Sabres | L | 3-0 |
| NHL | 2022/03/05 00:00 | MIN Wild v BUF Sabres | W | 4-5 |
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