[6] Carlisle 2-3 Leyton Orient [2] 2022-10-22 14:00
Stadium: Brunton Park Round: 15
Referee: Thomas Parsons Home Manager: Paul Simpson Away Manager: Richie Wellens
Head to Head
| England League 2 | 2022/02/26 15:00 | Leyton Orient v Carlisle | W | 0-1 |
| England League 2 | 2021/08/21 14:00 | Carlisle v Leyton Orient | D | 1-1 |
| England League 2 | 2021/05/01 14:00 | Leyton Orient v Carlisle | W | 2-3 |
| England League 2 | 2021/03/23 18:30 | Carlisle v Leyton Orient | L | 0-1 |
| England League 2 | 2019/10/26 14:00 | Leyton Orient v Carlisle | D | 1-1 |
| England League 2 | 2017/02/04 15:00 | Leyton Orient v Carlisle | W | 1-2 |
| England League 2 | 2016/09/10 14:00 | Carlisle v Leyton Orient | D | 2-2 |
| England League 2 | 2016/03/01 19:45 | Carlisle v Leyton Orient | D | 2-2 |
Home History
| England EFL Trophy | 2022/10/18 18:00 | Barrow v Carlisle | L | 2-0 |
| England League 2 | 2022/10/15 14:00 | Carlisle v Doncaster | W | 3-0 |
| England League 2 | 2022/10/08 14:00 | Hartlepool v Carlisle | W | 1-3 |
| England League 2 | 2022/10/01 14:00 | Carlisle v Crewe | D | 0-0 |
| England League 2 | 2022/09/27 18:45 | Grimsby v Carlisle | W | 1-2 |
| England League 2 | 2022/09/24 14:00 | Newport County v Carlisle | D | 1-1 |
| England EFL Trophy | 2022/09/20 18:00 | Carlisle v Fleetwood Town | W | 5-3 |
| England League 2 | 2022/09/17 14:00 | Carlisle v AFC Wimbledon | W | 2-1 |
Away History
| England EFL Trophy | 2022/10/18 19:30 | Leyton Orient v Chelsea U21 | L | 2-3 |
| England League 2 | 2022/10/15 14:00 | Leyton Orient v Northampton | D | 0-0 |
| England League 2 | 2022/10/08 14:00 | Doncaster v Leyton Orient | D | 1-1 |
| England League 2 | 2022/10/01 14:00 | Leyton Orient v Newport County | L | 1-2 |
| England League 2 | 2022/09/24 14:00 | Barrow v Leyton Orient | W | 0-2 |
| England EFL Trophy | 2022/09/20 18:00 | Leyton Orient v Sutton Utd | W | 3-1 |
| England League 2 | 2022/09/17 14:00 | Leyton Orient v Walsall | W | 1-0 |
| England League 2 | 2022/09/13 18:45 | Rochdale v Leyton Orient | W | 0-1 |
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