Stadium: Memorial Stadium (Texas A&M–Commerce) Round: 1
Home Manager: David Bailiff Away Manager: Brad Laird
| NCAAF | 2022/10/22 18:00 | SE Missouri St v Northwestern State | L | 51-16 |
| NCAAF | 2022/10/15 23:00 | Northwestern State v Houston Christian | W | 37-10 |
| NCAAF | 2022/10/08 19:00 | Northwestern State v Eastern Illinois | L | 27-35 |
| NCAAF | 2022/10/01 20:30 | Nicholls State v Northwestern State | W | 33-36 |
| NCAAF | 2022/09/24 20:30 | Lamar v Northwestern State | W | 27-35 |
| NCAAF | 2022/09/17 23:00 | Northwestern State v Southern Mississippi | L | 10-64 |
| NCAAF | 2022/09/10 23:00 | Grambling State v Northwestern State | L | 47-21 |
| NCAAF | 2022/09/03 19:00 | Northwestern State v Montana | L | 0-47 |
| NCAAF | 2022/10/29 19:00 | Incarnate Word v Texas A&M-Commerce | L | 35-7 |
| NCAAF | 2022/10/22 19:00 | Houston Christian v Texas A&M-Commerce | W | 3-31 |
| NCAAF | 2022/10/16 00:00 | Texas A&M-Commerce v McNeese State | W | 40-15 |
| NCAAF | 2022/10/08 21:00 | Texas A&M-Commerce v SE Louisiana | W | 31-28 |
| NCAAF | 2022/09/24 23:00 | Texas A&M-Commerce v North American Stallions | W | 63-3 |
| NCAAF | 2022/09/17 23:00 | Texas A&M-Commerce v Sam Houston State | L | 17-27 |
| NCAAF | 2022/09/10 23:00 | Texas A&M-Commerce v Tennessee Tech | L | 25-26 |
| NCAAF | 2022/09/02 00:00 | Texas A&M-Commerce v Lincoln Oaklanders | W | 52-7 |