Stadium: O'Brien Stadium Round: 1
Home Manager: Chris Wilkerson Away Manager: Rusty Wright
| NCAAF | 2022/09/03 22:00 | Wofford v Tennessee Chattanooga | W | 0-31 |
| NCAAF | 2021/11/20 18:30 | The Citadel v Tennessee Chattanooga | L | 24-21 |
| NCAAF | 2021/11/13 20:00 | Tennessee Chattanooga v Mercer | L | 6-10 |
| NCAAF | 2021/11/06 17:30 | Tennessee Chattanooga v Wofford | W | 35-10 |
| NCAAF | 2021/10/30 17:30 | Furman v Tennessee Chattanooga | W | 3-13 |
| NCAAF | 2021/10/23 17:00 | Tennessee Chattanooga v Samford | W | 55-13 |
| NCAAF | 2021/10/16 17:30 | East Tennessee State v Tennessee Chattanooga | W | 16-21 |
| NCAAF | 2021/10/09 17:30 | Tennessee Chattanooga v VMI | L | 34-37 |
| NCAAF | 2022/09/02 00:00 | Eastern Illinois v Northern Illinois | L | 27-34 |
| NCAAF | 2021/11/20 18:00 | Murray State v Eastern Illinois | L | 20-13 |
| NCAAF | 2021/11/06 19:00 | Eastern Illinois v Austin Peay | L | 26-42 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | L | 15-38 |
| NCAAF | 2021/10/23 19:00 | Tennessee State v Eastern Illinois | L | 28-0 |
| NCAAF | 2021/10/16 19:00 | Tennessee Martin v Eastern Illinois | L | 28-17 |
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | L | 6-22 |
| NCAAF | 2021/09/25 18:30 | Eastern Illinois v Tennessee Tech | W | 28-14 |