Stadium: Jack Spinks Stadium Round: 1
Home Manager: Fred McNair Away Manager: Terry Sims
| NCAAF | 2022/11/05 20:00 | Alabama State v Bethune Cookman | L | 37-22 |
| NCAAF | 2022/10/29 19:00 | Bethune Cookman v Prairie View | L | 48-58 |
| NCAAF | 2022/10/22 20:00 | Bethune Cookman v Mississippi Valley State | W | 45-35 |
| NCAAF | 2022/10/15 20:00 | Jackson State v Bethune Cookman | L | 48-8 |
| NCAAF | 2022/10/08 22:00 | Bethune Cookman v Tennessee State | L | 17-41 |
| NCAAF | 2022/10/01 19:00 | Bethune Cookman v Alabama | L | 27-35 |
| NCAAF | 2022/09/24 18:00 | Grambling State v Bethune Cookman | W | 19-36 |
| NCAAF | 2022/09/10 20:00 | South Carolina State v Bethune Cookman | L | 33-9 |
| NCAAF | 2022/11/04 23:30 | Alcorn State v Prairie View | W | 23-16 |
| NCAAF | 2022/10/29 19:00 | Alcorn State v Grambling State | L | 6-35 |
| NCAAF | 2022/10/22 19:00 | Texas Southern Tigers v Alcorn State | L | 34-27 |
| NCAAF | 2022/10/15 23:00 | Alcorn State v Southern | L | 17-21 |
| NCAAF | 2022/10/08 23:00 | Alcorn State v Mississippi Valley State | W | 30-7 |
| NCAAF | 2022/09/24 23:00 | Arkansas Pine Bluff v Alcorn State | W | 21-38 |
| NCAAF | 2022/09/18 00:00 | Alcorn State v McNeese State | W | 30-19 |
| NCAAF | 2022/09/10 23:00 | Alcorn State v Tulane | L | 0-52 |