Stadium: Seibert Stadium Round: 1
Home Manager: Chris Hatcher Away Manager: George Quarles
| NCAAF | 2022/10/22 19:30 | Samford v East Tennessee State | L | 55-45 |
| NCAAF | 2021/09/25 19:00 | East Tennessee State v Samford | W | 55-48 |
| NCAAF | 2021/02/20 18:00 | Samford v East Tennessee State | W | 17-24 |
| NCAAF | 2019/10/26 17:00 | East Tennessee State v Samford | L | 17-24 |
| NCAAF FCS | 2018/11/17 18:00 | Samford v East Tennessee State | L | 38-27 |
| NCAAF | 2017/11/11 20:00 | Samford v East Tennessee State | L | 42-7 |
| NCAAF | 2023/09/16 23:00 | East Tennessee State v Austin Peay | L | 3-63 |
| NCAAF | 2023/09/09 21:30 | East Tennessee State v Carson–Newman Eagles | W | 42-0 |
| NCAAF | 2023/09/02 18:00 | East Tennessee State v Jacksonville State | L | 3-49 |
| NCAAF | 2022/11/19 17:00 | East Tennessee State v Mississippi State | L | 7-56 |
| NCAAF | 2022/11/12 18:00 | Western Carolina v East Tennessee State | L | 20-17 |
| NCAAF | 2022/10/29 17:30 | East Tennessee State v Wofford | L | 41-48 |
| NCAAF | 2022/10/22 19:30 | Samford v East Tennessee State | L | 55-45 |
| NCAAF | 2022/10/15 20:00 | East Tennessee State v Mercer | L | 33-55 |
| NCAAF | 2023/09/23 19:00 | Tennessee Chattanooga v Samford | L | 47-24 |
| NCAAF | 2023/09/16 23:00 | Samford v Auburn | L | 13-45 |
| NCAAF | 2023/09/09 18:30 | Samford v Western Carolina | L | 7-30 |
| NCAAF | 2023/08/31 23:00 | Samford v Shorter Hawks | W | 69-14 |
| NCAAF | 2022/12/10 00:00 | Samford v North Dakota State | L | 9-27 |
| NCAAF | 2022/12/03 20:00 | SE Louisiana v Samford | W | 42-48 |
| NCAAF | 2022/11/19 18:00 | Mercer v Samford | W | 44-50 |
| NCAAF | 2022/11/12 18:30 | Samford v Tennessee Chattanooga | W | 35-24 |