Stadium: Caesars Superdome Round: 1
Home Manager: Hue Jackson Away Manager: Terrence Graves
| NCAAF | 2022/11/26 19:00 | Grambling State v Southern | W | 17-34 |
| NCAAF | 2021/11/27 22:00 | Southern v Grambling State | L | 26-29 |
| NCAAF | 2021/04/17 18:30 | Grambling State v Southern | W | 7-49 |
| NCAAF | 2019/11/30 22:00 | Southern v Grambling State | W | 30-28 |
| NCAAF FCS | 2018/11/24 22:00 | Grambling State v Southern | W | 28-38 |
| NCAAF | 2017/11/25 22:00 | Grambling State v Southern | L | 30-21 |
| NCAAF | 2023/11/11 20:00 | Prairie View v Southern | L | 27-21 |
| NCAAF | 2023/11/04 19:00 | Southern v Alcorn State | L | 21-44 |
| NCAAF | 2023/10/28 21:00 | Texas Southern Tigers v Southern | W | 17-23 |
| NCAAF | 2023/10/21 20:00 | Southern v Bethune Cookman | W | 28-18 |
| NCAAF | 2023/10/14 21:00 | Southern v Lincoln Oaklanders | W | 45-18 |
| NCAAF | 2023/10/07 23:00 | Florida A&M v Southern | L | 26-19 |
| NCAAF | 2023/09/30 21:00 | Southern v Arkansas Pine Bluff | W | 27-0 |
| NCAAF | 2023/09/16 23:00 | Alabama v Southern | W | 10-20 |
| NCAAF | 2023/11/11 02:00 | Grambling State v Arkansas Pine Bluff | W | 43-14 |
| NCAAF | 2023/11/04 21:00 | Grambling State v Alabama State | L | 6-17 |
| NCAAF | 2023/10/28 19:00 | Bethune Cookman v Grambling State | W | 14-28 |
| NCAAF | 2023/10/14 19:00 | Alabama v Grambling State | L | 45-24 |
| NCAAF | 2023/10/07 19:30 | Grambling State v Alcorn State | L | 24-25 |
| NCAAF | 2023/09/30 23:00 | Grambling State v Prairie View | W | 35-20 |
| NCAAF | 2023/09/23 19:00 | Texas Southern Tigers v Grambling State | W | 23-35 |
| NCAAF | 2023/09/16 19:00 | Grambling State v Florida Memorial University Lions | W | 58-22 |