[5] Alexander Zverev 3-6,7-6,10-7 John Isner [10] 2018-09-22 18:00
Stadium: United Center Round: 44 Ground: Hardcourt indoor
Head to Head
| ATP Madrid | 2018/05/11 20:00 | John Isner v Alexander Zverev | 4-6,5-7 |
| ATP Miami | 2018/04/01 17:00 | Alexander Zverev v John Isner | 7-6,4-6,4-6 |
| ATP Rome | 2017/05/20 13:00 | Alexander Zverev v John Isner | 6-4,6-7,6-1 |
| ATP Miami | 2017/03/27 20:40 | John Isner v Alexander Zverev | 7-6,6-7,6-7 |
| ATP Shanghai | 2016/10/10 07:10 | Alexander Zverev v John Isner | 6-4,6-2 |
Home History
| US Open | 2018/09/01 20:15 | Philipp Kohlschreiber v Alexander Zverev | 6-7,6-4,6-1,6-3 |
| US Open | 2018/08/30 17:05 | Nicolas Mahut v Alexander Zverev | 4-6,4-6,2-6 |
| US Open | 2018/08/28 19:45 | Peter Polansky v Alexander Zverev | 2-6,1-6,2-6 |
| ATP Cincinnati | 2018/08/15 15:00 | Alexander Zverev v Robin Haase | 7-5,4-6,5-7 |
| ATP Toronto | 2018/08/10 17:55 | Stefanos Tsitsipas v Alexander Zverev | 3-6,7-6,6-4 |
| ATP Toronto | 2018/08/09 20:25 | Daniil Medvedev v Alexander Zverev | 3-6,2-6 |
| ATP Toronto | 2018/08/08 23:35 | Bradley Klahn v Alexander Zverev | 4-6,4-6 |
| ATP Washington | 2018/08/05 19:00 | Alexander Zverev v Alex De Minaur | 6-2,6-4 |
Away History
| US Open | 2018/09/04 17:45 | Juan Martin Del Potro v John Isner | 6-7,6-3,7-6,6-2 |
| US Open | 2018/09/02 19:45 | John Isner v Milos Raonic | 3-6,6-3,6-4,3-6,6-2 |
| US Open | 2018/08/31 21:00 | John Isner v Dusan Lajovic | 7-6,6-7,6-3,7-5 |
| US Open | 2018/08/29 20:45 | John Isner v Nicolas Jarry | 6-7,6-4,3-6,7-6,6-4 |
| US Open | 2018/08/27 16:50 | John Isner v Bradley Klahn | 7-6,6-3,6-4 |
| ATP Cincinnati | 2018/08/13 20:15 | John Isner v Sam Querrey | 4-6,7-6,6-7 |
| ATP Toronto | 2018/08/09 22:40 | Karen Khachanov v John Isner | 7-6,7-6 |
| ATP Toronto | 2018/08/08 20:00 | Pierre-Hugues Herbert v John Isner | 6-7,2-6 |
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