| Challenger Bratislava | 11/05 15:30 | 25 | [104] Guillermo Garcia-Lopez v Daniel Brands [173] | 7-6,6-4 | |
| Challenger Eckental | 10/31 13:45 | 26 | [231] Gleb Sakharov v Guillermo Garcia-Lopez [106] | 6-4,7-6 | |
| Challenger Eckental | 10/29 14:40 | 25 | [144] Quentin Halys v Guillermo Garcia-Lopez [106] | 6-7,6-7 | |
| ATP Basel | 10/20 15:15 | 64 | [94] Guillermo Garcia-Lopez v Vasek Pospisil [79] | 2-6,2-6 | |
| ATP Stockholm | 10/15 13:30 | 25 | [63] Denis Kudla v Guillermo Garcia-Lopez [94] | 6-2,7-5 | |
| ATP Shenzhen | 09/24 08:10 | 25 | [81] Guillermo Garcia-Lopez v Viktor Troicki [131] | Retired | |
| ATP St Petersburg | 09/18 11:45 | 25 | [80] Guillermo Garcia-Lopez v Matteo Berrettini [62] | 6-7,6-2,3-6 | |
| US Open | 08/28 17:00 | 23 | Guillermo Garcia-Lopez v Jaume Munar | Cancelled | |
| ATP Winston-Salem | 08/21 00:30 | 25 | [23] Hyeon Chung v Guillermo Garcia-Lopez [69] | 7-6,6-2 | |
| ATP Winston-Salem | 08/19 22:10 | 24 | [93] Marcos Baghdatis v Guillermo Garcia-Lopez [71] | 6-7,4-6 | |
| ATP Cincinnati | 08/15 23:15 | 25 | [71] Guillermo Garcia-Lopez v Marton Fucsovics [48] | 7-6,4-6,5-7 | |
| ATP Cincinnati Qual | 08/12 14:00 | 46 | [116] Bradley Klahn v Guillermo Garcia-Lopez [73] | 7-6,7-6 | |
| ATP Cincinnati Qual | 08/11 14:00 | 45 | [95] Ricardas Berankis v Guillermo Garcia-Lopez [73] | 4-6,3-6 | |
| ATP Kitzbuhel | 07/30 13:20 | 25 | [71] Guillermo Garcia-Lopez v Dusan Lajovic [66] | 4-6,2-6 | |
| ATP Gstaad | 07/23 10:55 | 25 | Guillermo Garcia-Lopez v Roberto Carballes Baena | 6-7,2-6 | |
| Wimbledon | 07/04 12:05 | 24 | [65] Guillermo Garcia-Lopez v Daniil Medvedev [67] | 3-6,4-6,2-6 | |
| Wimbledon | 07/02 12:55 | 23 | [65] Guillermo Garcia-Lopez v Gastao Elias [118] | 6-2,6-4,6-2 | |
| ATP Antalya | 06/28 14:30 | 27 | [41] Gael Monfils v Guillermo Garcia-Lopez [69] | 7-6,6-4 | |
| ATP Antalya | 06/27 10:30 | 26 | [69] Guillermo Garcia-Lopez v Robin Haase [44] | 6-2,6-7,7-6 | |
| ATP Antalya | 06/25 13:10 | 25 | [70] Guillermo Garcia-Lopez v Taro Daniel [86] | 6-4,6-7,6-4 | |
| ATP Hertogenbosch | 06/12 13:35 | 25 | [68] Guillermo Garcia-Lopez v Jeremy Chardy [72] | 4-6,7-6,6-7 | |
| Challenger Prostejov | 06/08 11:30 | 28 | [67] Guillermo Garcia-Lopez v Laslo Djere [101] | 6-7,6-3,6-7 | |
| Challenger Prostejov | 06/07 15:20 | 27 | [67] Guillermo Garcia-Lopez v Federico Gaio [314] | 6-3,6-4 | |
| Challenger Prostejov | 06/06 16:05 | 26 | [67] Guillermo Garcia-Lopez v Thomaz Bellucci [278] | 6-1,7-6 | |
| Challenger Prostejov | 06/05 10:35 | 25 | [67] Guillermo Garcia-Lopez v Gleb Sakharov [210] | 6-4,6-4 | |
| French Open | 05/30 15:15 | 24 | [38] Karen Khachanov v Guillermo Garcia-Lopez [67] | 6-2,7-6,6-7,6-3 | |
| French Open | 05/28 09:00 | 23 | [67] Guillermo Garcia-Lopez v Stan Wawrinka [30] | 6-2,3-6,4-6,7-6,6-3 | |
| ATP Lyon | 05/24 16:25 | 27 | [8] Dominic Thiem v Guillermo Garcia-Lopez [71] | 6-7,7-6,6-4 | |
| ATP Lyon | 05/22 11:40 | 26 | [127] Calvin Hemery v Guillermo Garcia-Lopez [71] | 6-7,3-6 | |
| ATP Lyon | 05/21 11:20 | 25 | [71] Guillermo Garcia-Lopez v Adrian Mannarino [27] | 6-3,4-6,6-1 |