| Argentina Reserve League | 07/13 14:00 | 25 | [8] San Lorenzo Reserves v Belgrano Reserves [2] | L | 0-1 | |
| Argentina Reserve League | 07/08 14:00 | 24 | [4] River Plate Reserves v San Lorenzo Reserves [6] | L | 4-0 | |
| Argentina Reserve League | 07/03 14:00 | 23 | [9] San Lorenzo Reserves v Racing Club Reserves [2] | W | 3-0 | |
| Argentina Reserve League | 06/26 14:00 | 22 | [12] Rosario Central Reserves v San Lorenzo Reserves [4] | L | 4-0 | |
| Argentina Reserve League | 06/19 17:00 | 21 | [9] San Lorenzo Reserves v Estudiantes LP Reserves [4] | W | 1-0 | |
| Argentina Reserve League | 06/09 14:00 | 20 | [19] Central Cordoba SdE Reserves v San Lorenzo Reserves [12] | W | 0-3 | |
| Argentina Reserve League | 06/02 14:00 | 19 | [15] Colon Reserves v San Lorenzo Reserves [11] | D | 0-0 | |
| Argentina Reserve League | 05/27 17:00 | 18 | [15] San Lorenzo Reserves v Barracas Central Reserves [21] | W | 1-0 | |
| Argentina Reserve League | 05/18 14:00 | 17 | [20] Instituto AC Cordoba Reserves v San Lorenzo Reserves [16] | W | 1-2 | |
| Argentina Reserve League | 05/11 14:00 | 16 | [15] San Lorenzo Reserves v Banfield Reserves [14] | W | 1-0 | |
| Argentina Reserve League | 05/05 14:00 | 15 | [7] Defensa y Justicia Reserves v San Lorenzo Reserves [15] | L | 2-1 | |
| Argentina Reserve League | 04/28 14:00 | 14 | [13] San Lorenzo Reserves v Velez Sarsfield Reserves [1] | D | 1-1 | |
| Argentina Reserve League | 04/21 14:00 | 13 | [28] Platense Reserves v San Lorenzo Reserves [13] | L | 1-0 | |
| Argentina Reserve League | 04/14 14:00 | 12 | [8] San Lorenzo Reserves v CA Talleres de Córdoba Reserves [14] | L | 2-3 | |
| Argentina Reserve League | 04/10 23:00 | 11 | [17] Boca Juniors Reserves v San Lorenzo Reserves [7] | L | 1-0 | |
| Argentina Reserve League | 04/05 14:00 | 10 | [3] San Lorenzo Reserves v Atletico Tucuman Reserves [24] | D | 2-2 | |
| Argentina Reserve League | 03/31 14:00 | 9 | [8] CA Independiente Reserves v San Lorenzo Reserves [3] | D | 1-1 | |
| Argentina Reserve League | 03/17 12:00 | 8 | [4] San Lorenzo Reserves v Newell's Reserves [20] | W | 1-0 | |
| Argentina Reserve League | 03/09 12:00 | 7 | [20] Gimnasia LP Reserves v San Lorenzo Reserves [8] | W | 0-1 | |
| Argentina Reserve League | 03/04 12:00 | 6 | [8] San Lorenzo Reserves v Huracan Reserves [13] | D | 0-0 | |
| Argentina Reserve League | 02/24 12:00 | 5 | [23] Union Santa Fe Reserves v San Lorenzo Reserves [12] | W | 1-2 | |
| Argentina Reserve League | 02/17 12:00 | 4 | [14] San Lorenzo Reserves v Sarmiento Reserves [23] | W | 1-0 | |
| Argentina Reserve League | 02/12 12:00 | 3 | [24] Godoy Cruz Reserves v San Lorenzo Reserves [24] | W | 0-2 | |
| Argentina Reserve League | 02/05 18:00 | 2 | Lanus Reserves v San Lorenzo Reserves | - | Cancelled | |
| Argentina Reserve League | 02/05 12:00 | 2 | [21] San Lorenzo Reserves v Lanus Reserves [7] | L | 1-2 | |
| Argentina Reserve League | 01/29 12:00 | 1 | [14] Arsenal de Sarandi Reserves v San Lorenzo Reserves [14] | D | 0-0 | |
| Argentina Reserve League | 01/27 18:00 | 1 | San Lorenzo Reserves v Arsenal de Sarandi Reserves | - | Cancelled | |
| Argentina Reserve League | 10/23 13:00 | 27 | [26] CA Aldosivi Reserves v San Lorenzo Reserves [16] | W | 2-3 | |
| Argentina Reserve League | 10/18 14:00 | 26 | [16] San Lorenzo Reserves v CA Sarmiento Reserves [23] | D | 0-0 | |
| Argentina Reserve League | 10/14 14:00 | 25 | [18] San Lorenzo Reserves v Gimnasia LP Reserves [10] | W | 3-1 |