| US Open | 08/27 15:00 | 23 | [127] Gilles Muller v Lorenzo Sonego [121] | 6-7,7-6,7-5,6-7,2-6 | |
| Challenger Vancouver | 08/15 19:00 | 26 | [117] Gilles Muller v Yannick Maden [131] | 4-6,6-7 | |
| Challenger Vancouver | 08/14 19:35 | 25 | [117] Gilles Muller v Christopher Eubanks [205] | 6-4,4-6,6-3 | |
| ATP Los Cabos | 08/01 03:00 | 25 | [104] Gilles Muller v Quentin Halys [150] | 4-6,4-6 | |
| ATP Newport | 07/18 17:00 | 26 | [124] Marcel Granollers v Gilles Muller [95] | 7-5,7-6 | |
| ATP Newport | 07/17 16:25 | 25 | [96] Marcos Baghdatis v Gilles Muller [95] | 6-7,3-6 | |
| Wimbledon | 07/04 16:00 | 24 | [27] Philipp Kohlschreiber v Gilles Muller [60] | 7-6,7-6,7-6 | |
| Wimbledon | 07/02 10:30 | 23 | [60] Gilles Muller v Michael Mmoh [119] | 7-5,4-6,7-6,3-6,6-1 | |
| ATP Eastbourne | 06/25 11:55 | 25 | [46] Gilles Muller v John Millman [63] | 7-6,3-6,2-6 | |
| ATP Queens | 06/20 15:25 | 26 | [6] Marin Cilic v Gilles Muller [46] | 4-6,6-3,6-3 | |
| ATP Queens | 06/18 11:00 | 25 | [23] Denis Shapovalov v Gilles Muller [46] | 6-7,6-7 | |
| ATP Hertogenbosch | 06/13 13:25 | 26 | [32] Gilles Muller v Matthew Ebden [69] | 3-6,5-7 | |
| French Open | 05/28 09:00 | 23 | [160] Ernests Gulbis v Gilles Muller [34] | 2-6,6-4,6-4,6-3 | |
| ATP Rome | 05/14 09:00 | 24 | [65] Aljaz Bedene v Gilles Muller [35] | 6-4,6-4 | |
| ATP Estoril | 05/02 17:00 | 26 | [64] Frances Tiafoe v Gilles Muller [28] | 6-4,7-5 | |
| ATP Monte Carlo | 04/17 16:35 | 25 | [28] Gilles Muller v Alexander Zverev [4] | 6-4,3-6,2-6 | |
| ATP Monte Carlo | 04/16 13:35 | 24 | [74] Florian Mayer v Gilles Muller [28] | 5-7,4-6 | |
| Davis Cup | 04/08 10:30 | 27 | Gilles Muller v George Tsivadze | Cancelled | |
| Davis Cup | 04/07 13:00 | 27 | Gilles Muller v Zura Tkemaladze | 6-3,6-2 | |
| ATP Miami | 03/23 21:10 | 24 | [102] Mikhail Youzhny v Gilles Muller [28] | 4-6,6-4,6-2 | |
| ATP Indian Wells | 03/11 18:00 | 24 | Pierre-Hugues Herbert v Gilles Muller | 6-3,7-5 | |
| ATP Marseille | 02/22 14:40 | 26 | Gilles Muller v Nicolas Mahut | 6-3,2-6,4-6 | |
| ATP Marseille | 02/21 13:00 | 25 | Gilles Muller v Sergiy Stakhovsky | 7-5,6-3 | |
| ATP Marseille | 02/21 12:20 | - | Gilles Muller v Daniil Medvedev | Cancelled | |
| ATP Rotterdam | 02/13 12:55 | 25 | Daniil Medvedev v Gilles Muller | 6-4,7-6 | |
| ATP Rotterdam | 02/12 09:00 | 25 | Joao Sousa v Gilles Muller | Cancelled | |
| ATP Sofia | 02/09 10:00 | 27 | Marius Copil v Gilles Muller | 6-4,6-4 | |
| ATP Sofia | 02/08 10:00 | 26 | Andreas Seppi v Gilles Muller | 6-4,6-7,6-7 | |
| Australian Open | 01/19 01:35 | 25 | Pablo Carreno-Busta v Gilles Muller | 7-6,4-6,7-5,7-5 | |
| Australian Open | 01/17 00:00 | 24 | Malek Jaziri v Gilles Muller | 5-7,4-6,7-6,6-3,2-6 |